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KMID : 1103720080580010053
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Journal of the Korean Society of Radiology
2008 Volume.58 No. 1 p.53 ~ p.63
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Comparison of Ferucarbortan-Enhanced MRI And Triple-Phase MDCT for the Detection of Hepatocellular Carcinoma in Advanced Liver Cirrhosis
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Jeon Yong-Hwan
Han Heon
Kim Seung-Hoon
Choi Dong-Il
Kim Min-Ju
Kim Sam-Soo
Lee Ji-Won
Lee Jong-Mee
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Abstract
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Purpose: To compare the diagnostic performance of ferucarbotran-enhanced MRI at 1.5-T with triple-phase multidetector-row helical CT (MDCT) to detect hepatocellular carcinoma in patients with advanced liver cirrhosis.
Materials and Methods: Twenty patients with advanced liver cirrhosis (Child’s class B:C = 8:12) underwent ferucarbotran-enhanced MRI and triple-phase MDCT prior to liver transplantation. The mean time interval between the two imaging techniques was 18 days (range, 1-35 days). Three radiologists independently reviewed both images on a lesion-by-lesion basis and interpreted them for comparison with the pathologic findings of the explanted livers. As well, the sensitivity and an alternative-free response receiver operating characteristics (ROC) analysis was used to evaluate the diagnostic performance of each technique.
Results: The mean area under the ROC curve (Az) was significantly higher for the triple-phase MDCT (0.766) compared to the ferucarbotran-enhanced MRI (0.675) (p < 0.001). Similarly, the mean sensitivity of the triple-phase MDCT (60.3%) exceeded the ferucarbotran-enhanced MRI (43.1%). The results indicate that the triple-phase MDCT provides significantly greater mean sensitivity than the ferucarbotran-enhanced MRI (p < 0.001).
Conclusion: The triple-phase MDCT provided a better diagnostic performance and higher sensitivity than the ferucarbotran-enhanced MRI for the detection of hepatocellular carcinomas in patients with advanced liver cirrhosis.
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KEYWORD
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Carcinoma, hepatocellular, Liver cirrhosis, Magnetic resonance(MR), Tomography, spiral computed Ferumoxides
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